The town I live in was the area that was most affected by the earthquake.
The earthquake we had last week hit our town the hardest.
ーThe town I live in was the area that was most affected by the earthquake.
「私の住む町はその地震で最も影響を受けた地域でした」
area that was most affected by the earthquake「その地震で最も影響を受けた地域」を使って表現できるかと思います。
ーThe earthquake we had last week hit our town the hardest.
「先週のその地震は、私の街を最もひどく襲った」
to hit one's town hardest で「最もひどく襲う・最も大きな打撃を与える」を使っても表現できます。
ご参考まで！
カナダ 
