Despite his/her disability, he/she led an active life in many ways.
He/she also gave hope to other disabled people.
ご質問ありがとうございます。
"Despite his/her disability,"=「彼(女)の障害にかかわらず」
"he/she led an active life in many ways."=「いろいろな面で活躍された。」
"He/she also gave hope to other disabled people."=「彼(女)は他の障害者の人々に希望を与えた。」
ご参考になると幸いです。