In this instance, we haven't gotten approval from Mr. X yet, is there an issue with the application?
This hasn't been approved by Mr. X yet; has there been a problem with the application?
ご質問どうもありがとうございます。
様々な表現があると思いますが、いくつか自然な表現を紹介します。
1. In this instance, we haven't gotten approval from Mr. X yet, is there an issue with the application?
このケースは、Xさんから未だ承認を頂いていませんが申請に問題あります？
2. This hasn't been approved by Mr. X yet; has there been a problem with the application?
--- issue = problem
お好みに合わせて使い分けてみてください。
ご参考にしていただければ幸いです。
ドイツ 
