「ランニングは体力を使う」と言う場合、次のように言うと自然で良いかと思います。
ーYou need endurance to run.
「走るのに体力が必要だ」
endurance で「持久力・耐久力」
ーYou have to have stamina to keep running.
「走り続けるのに体力がなければいけない」
stamina で「体力・持久力・スタミナ」
ご参考まで!
"Running takes a lot out of you."
"Running is really tiring."
"Running is exhausting."
"Running uses up a lot of energy."
"Running drains your energy."
"Running is hard on your body."
"Running can really wear you out."
英語では tiring / exhausting / wear you out / take a lot out of you を使うと自然です。