His girlfriend is using and abusing him and he doesn't even know it.
この場合、次のような言い方ができますよ。
ーHis girlfriend is using and abusing him and he doesn't even know it.
「彼の恋人は彼をいいように使っているけど、彼はそれに気がついていない」
ここの「使う」は to use and abuse someone のように言えます。
ご参考まで!
He doesn't realize that he is being used by his partner.
ご質問ありがとうございます。
"abuse"を使う場合は "he doesn't realize that he is being abused (by his partner/girlfriend/lover)" になりますが、abuseは身体的な暴力を含む場合が多いので、まだ「使われている」という段階でしたら、"being used"を使います。
例文:"My boss uses me like I'm his servant."=「上司は私が召使のように私を使う。」
ご参考に。