How do you feel about being back in the US after 2 years?
How's it like to be back home for the first time in two years?
(1) How do you feel about being back in the US after 2 years?
'being back after ~ years' = 「〜年ぶりの帰国」
「2年ぶりのアメリカはどう？」
(2) How's it like to be back home for the first time in two years?'
'be back home' ＝「帰国」「帰宅」
'first time in ~ years' = 「〜年ぶり」
「2年ぶりの帰国はどんな感じ？」というニュアンスの一例です。
日本 
