You're going to have to take off at least another 2000 yen from that price.
ーCan you come down at least another 2000 yen?
「最低あと2,000円値下げしてくれない?」
come down で「(値段を)下げる」
at least 「最低でも・少なくとも」
ーYou're going to have to take off at least another 2000 yen from that price.
「その値段から少なくともあと2,000円は値下げしくれないとね。」
take off で「(値段を)割り引く・まける」
ご参考まで!