"I was completely exhausted but speaking with you has really picked me up."
"I was completely exhausted but speaking with you has really picked me up."
"I was completely exhausted but~" 「疲労困憊だったが〜」
"speaking with you" 「あなたと談笑したら」”speaking" の代わりに "talking" や "chatting" も使えます。
"really picked me up" 「とても元気になった」