It doesn't matter how much or what you say because talking with someone who is useless at holding a conversation is a waste of time.
It's pointless trying to talk to someone who is a bad conversationalist
「まともに会話できない人」= someone who is bad at (making) conversations/a bad conversationalist/someone useless at holding a conversation
「無駄だ」= a waste of time/pointless
「いくら話しても」= it doesn't matter how much or what you say
組み合わせると:
It doesn't matter how much or what you say because talking with someone who is useless at holding a conversation is a waste of time.
又は
It's pointless trying to talk to someone who is a bad conversationalist