If I don't have nose drops, my nose gets so blocked up that I can't sleep.
If I don't use my nasal spray, my nose gets so blocked up that it is difficult to sleep.
At night, if I don't use my nasal spray I can't sleep because my nose gets so blocked up.
「点鼻薬がないと鼻が詰まって寝られない」= If I don't have nose drops, my nose gets so blocked up that I can't sleep. / If I don't use my nasal spray, my nose gets so blocked up that it is difficult to sleep. / At night, if I don't use my nasal spray I can't sleep because my nose gets so blocked up.
ボキャブラリー
if I don't have = ~がないと
nose drops/nasal spray = 点鼻薬
get blocked up = 詰まる
can't sleep = 寝られない
if I don't use = 使わないと
difficult to sleep = 寝づらい
at night = 夜