However busy you may be and however much you may not want to interrupt your work, you must make sure to give yourself a periodical break.
ご質問ありがとうございます。
"However busy you may be"＝「いくら忙しくても」
"and however much you may not want to interrupt your work"＝「そしていくら自分の仕事を中断したくなくても」
"you must make sure to give yourself a periodical break."=「定期的に休憩を取るようにしなければいけない。」
ご参考に！
アメリカ合衆国 
