My grandpa previously was very active and enjoyed going on walks but ever since he suffered his illness he has been unable to walk fast.
ご質問ありがとうございます。
「〜できなくなった」は英語で「unable to」と言います。
また、「私の祖父は以前は活発に歩けていたけど病気を患ってからは早く歩けなくなった」と説明したいなら、そうすると、「My grandpa previously was very active and enjoyed going on walks but ever since he suffered his illness he has been unable to walk fast.」になります。
ご参考になれば幸いです。