どんなお仕事をされているんですかって英語でなんて言うの？

英語の場合はできるだけ間接的な表現にすることで丁寧さや優しさを増した表現になることが多く、この場合は定番の聞き方が、“What do you do？”　又は “What do you do for a living?” と聞くのがベスト。

少なくとも “What is your job？” （あなたの義務（責任）は何ですか？）　とか、
"What is your work?"　とはネイティブなら聞かないでしょう。

1. What do you do?
   お仕事は何をされているんですか？

これが最も一般的な聞き方だと思います。直訳は「何をしていますか？」ですが、「お仕事は何をされているんですか？」の意味です。

例：
A: What do you do?　お仕事は何をされているんですか？
B: I'm a Japanese/English translator.　日英翻訳者です。

What do you do for a living? のように for a living を加えても良いです。

When asking someone what their job is, you need to be considerate with your choice of words, as some people consider it a personal question. Adding subtle wording to your sentences makes a world of difference. When we say "line of work", we are just politely asking what the field is in which they work. This is best suited if you are speaking to a stranger. You may also use "May I ask what you do for a living?" The words "do for a living" asks what they do to make money and survive.
If you just wish to be direct, then "What is your job?" would suffice wonderfully. Thank you for your question!

If you would like to know how to ask someone what they do for a living, you can say something like "What do you do for a living?" or "What do you do for work?". These are some easy ways to ask someone what it is they do for a living.